CD133-positive cells in hepatocellular carcinoma (HCC) display cancer stem cell (CSC)-like properties in addition to resistance to chemotherapeutic agents and radiation that is ionizing but, their function remains unknown. In this paper, we identified a hitherto unknown procedure to overcome CD133-induced resistance to therapy that is anticancer.
We applied a alternate approach to enrich the CD133-positive HCC populace by manipulating 3D culture conditions. Body’s defence mechanism against reactive oxygen species (ROS) in CSC spheroids had been assessed by fluorescence image-based phenotypic screening system. Further, we learned the result of sulfasalazine on ROS defense system and synergistic healing efficacy of anticancer therapies both in culture plus in vivo HCC xenograft mouse model. Continue reading “Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells”